The antihypertensive mechanism of chlorothiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large conductance calcium activated potassium KCa channel, also found in the smooth muscle can you take doxycycline with food link to original article contains dosing details in manuscript PubMed NCT00003128 GOG 0261 Powell MA, Filiaci VL, Hensley ML, Huang HQ, Moore KN, Tewari KS, Copeland LJ, Secord AA, Mutch DG, Santin A, Warshal DP, Spirtos NM, DiSilvestro PA, Ioffe OB, Miller DS